Stanley B Prusiner Selected Research

2-aminothiazole

1/2016	Optimization of Aryl Amides that Extend Survival in Prion-Infected Mice.
10/2015	Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains.
7/2015	Use of a 2-aminothiazole to Treat Chronic Wasting Disease in Transgenic Mice.
2/2011	2-Aminothiazoles as therapeutic leads for prion diseases.

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Stanley B Prusiner Research Topics

Disease

53	Prion Diseases (Transmissible Spongiform Encephalopathies) 05/2021 - 02/2002
33	Scrapie 05/2021 - 10/2000
31	Neurodegenerative Diseases (Neurodegenerative Disease) 05/2021 - 05/2007
22	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 05/2021 - 03/2002
16	Alzheimer Disease (Alzheimer's Disease) 05/2021 - 02/2004
16	Neuroblastoma 12/2013 - 10/2000
13	Infections 05/2021 - 03/2006
13	Bovine Spongiform Encephalopathy (Mad Cow Disease) 11/2016 - 03/2002
12	Multiple System Atrophy 01/2022 - 11/2013
10	Sporadic Creutzfeldt-Jakob Disease 04/2014 - 04/2003
8	Parkinson Disease (Parkinson's Disease) 01/2022 - 08/2009
6	Synucleinopathies 01/2022 - 11/2013
6	Gliosis 01/2016 - 10/2002
6	Chronic Wasting Disease 07/2015 - 11/2002
4	Tauopathies 02/2020 - 01/2013
3	Dementia (Dementias) 01/2022 - 02/2004
3	Disease Progression 01/2020 - 02/2004
3	Nervous System Diseases (Neurological Disorders) 10/2011 - 06/2003
2	Amyloid Plaque 01/2018 - 07/2014
2	Chronic Traumatic Encephalopathy 12/2017 - 12/2016
2	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 12/2017 - 09/2015
2	Fatal Familial Insomnia 11/2017 - 10/2016
2	Acquired CJD 11/2016 - 02/2012
2	Neurologic Manifestations (Neurological Manifestations) 12/2011 - 10/2002
2	Communicable Diseases (Infectious Diseases) 02/2008 - 06/2005
1	Frontotemporal Dementia (Semantic Dementia) 05/2021
1	Disease Susceptibility (Diathesis) 05/2021
1	Lewy Body Disease (Lewy Body Dementia) 01/2020
1	Proteostasis Deficiencies 01/2020
1	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 01/2018
1	Parkinsonian Disorders (Parkinsonism) 09/2015
1	Kuru 11/2013
1	Amyloidosis 07/2012
1	Pathologic Processes 08/2010
1	Atrophy 07/2008
1	Conversion Disorder (Astasia Abasia) 07/2008
1	Poliomyelitis (Polio) 05/2007
1	Burns 06/2003
1	Parasitic Diseases (Parasitic Disease) 06/2003

Drug/Important Bio-Agent (IBA)

92	PrionsIBA 01/2022 - 10/2000
54	Prion ProteinsIBA 05/2021 - 10/2000
22	Protein Isoforms (Isoforms)IBA 01/2018 - 10/2002
19	Proteins (Proteins, Gene)FDA Link 05/2021 - 05/2003
13	SynucleinsIBA 01/2022 - 11/2013
10	Pharmaceutical PreparationsIBA 01/2020 - 07/2008
10	Amyloid (Amyloid Fibrils)IBA 08/2018 - 12/2007
7	Peptides (Polypeptides)IBA 05/2021 - 06/2003
6	Quinacrine (Mepacrine)IBA 12/2013 - 03/2003
4	tau Proteins (tau Protein)IBA 12/2017 - 09/2013
4	2-aminothiazoleIBA 01/2016 - 02/2011
4	Peptide Hydrolases (Proteases)FDA Link 12/2011 - 11/2004
3	diazonaphthalenedisulfonic acid (NDS)IBA 05/2021 - 01/2013
3	Biological ProductsIBA 01/2018 - 03/2008
2	Nucleic AcidsIBA 05/2021 - 01/2020
2	Codon (Codons)IBA 10/2016 - 05/2003
2	AmidesIBA 01/2016 - 11/2013
2	Monoclonal AntibodiesIBA 10/2012 - 11/2004
2	AminesIBA 02/2011 - 03/2003
2	Aminacrine (Aminoacridine)IBA 04/2007 - 09/2006
1	thioflavin TIBA 01/2019
1	Flavin-Adenine Dinucleotide (FAD)IBA 01/2018
1	Isoleucine (L-Isoleucine)FDA Link 10/2016
1	AnionsIBA 05/2015
1	formic acid (formate)IBA 11/2013
1	Detergents (Detergent)IBA 11/2013
1	Endopeptidase K (Proteinase K)IBA 11/2013
1	HydrazonesIBA 11/2013
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 09/2013
1	EpitopesIBA 10/2012
1	ProteomeIBA 08/2010
1	EnzymesIBA 04/2010
1	ImmunosorbentsIBA 04/2010
1	Biomarkers (Surrogate Marker)IBA 09/2009
1	Immunoglobulin FragmentsIBA 03/2009
1	N2- ((2S)- 2- (3,5- difluorophenyl)- 2- hydroxyethanoyl)- N1- ((7S)- 5- methyl- 6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- L- alaninamideIBA 07/2008
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 07/2008
1	Transcription Factors (Transcription Factor)IBA 07/2008
1	Heavy MetalsIBA 11/2007
1	VaccinesIBA 05/2007
1	OligonucleotidesIBA 03/2007
1	DNA (Deoxyribonucleic Acid)IBA 03/2007
1	HDL LipoproteinsIBA 07/2006
1	LDL Lipoproteins (beta Lipoproteins)IBA 07/2006
1	A-factor (Streptomyces)IBA 01/2006
1	Immunoglobulins (Immunoglobulin)IBA 11/2004
1	Immunoglobulin G (IgG)IBA 11/2004
1	gamma-Aminobutyric Acid (GABA)IBA 08/2004
1	Presenilin-1IBA 02/2004
1	Complementary DNA (cDNA)IBA 05/2003
1	EstersIBA 03/2003
1	AcridinesIBA 03/2003
1	bis-acridineIBA 03/2003
1	carbamic acid (ammonium carbamate)IBA 03/2003
1	TunicamycinIBA 10/2000

Therapy/Procedure

7	Therapeutics 10/2020 - 02/2011
1	Oral Administration 02/2011
1	Immunotherapy 03/2009